The CB2 receptor and its role as a regulator of inflammation (Cell Mol Life Sci. 2016; 73(23): 4449-70.)

Targeting CB2 receptors and the endocannabinoid system for the treatment of pain (Brain Res Rev. 2009 Apr; 60(1): 255-266.)

Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain (Br J Pharmacol. 2008 Jan; 153(2): 319–334.)

The central cannabinoid receptor type-2 (CB2) and chronic pain (Int J Neurosci. 2017 Sep;127(9):812-823.)

A CB2 receptor agonist attenuates bone cancer-induced pain and bone loss (Life Sci. 2010 Apr 24; 86(17-18): 646–653.)

β-Caryophyllene, a CB2-Receptor-Selective Phytocannabinoid, Suppresses Mechanical Allodynia in a Mouse Model of Antiretroviral-Induced Neuropathic Pain (Molecules. 2019 Dec 27;25(1):106.)

β-Caryophyllene, a CB2-Receptor-Selective Phytocannabinoid, Suppresses Mechanical Allodynia in a Mouse Model of Antiretroviral-Induced Neuropathic Pain (Molecules. 2019 Dec 27;25(1):106. )

Anxious behavior induces elevated hippocampal CB2 expression (Neuroscience. 2017 Jun 3;352:273-284.)

Regulatory role of the CB2 receptor in stress-induced neuroinflammation (Br J Pharmacol. 2014 Jun;171(11):2814-26.)

β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice (Physiol Behav. 2014 Aug;135:119-24.)

CB2 receptor agonist improves systemic sensitivity to insulin (Cell Physiol Biochem. 2016;40(5):1175-1185.)

Therapeutic potential of CB2 in the treatment of diabetes mellitus and its complications (Eur J Pharmacol. 2019 Nov 5;862:172628.)

Anti-Obesity Effect of a CB2 Receptor Agonist in Diet-Induced Obese Mice (PLoS One. 2015 Nov 20;10(11):e0140592.)

CB2 as Antiobesity Target: Inflammation, Fat Storage, and Browning Modulation (J Clin Endocrinol Metab. 2016 Sep;101(9):3469-78.)

CB2 receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell (Cell Calcium. 2006 Feb;39(2):155-62.)

β-caryophyllene, a CB2 agonist, decreases the motivational salience and conditioning place preference for palatable food in female mice (Addict Biol. 2023 Jan;28(1):e13249.)

Beta-caryophyllene alleviates diet-induced neurobehavioral changes in rats: The role of CB2 and PPAR-γ receptors (Biomed Pharmacother. 2019 Feb:110:145-154. )

CB2 drives neurogenesis and improves functional outcome after stroke (Stroke. 2017 Jan;(48)1:204-212.)

Prospects for creation of cardioprotective drugs based on cannabinoid receptor agonists (J Cardiovasc Pharmacol Ther. 2016 May;21(3):262-72.)

CB2 in atherosclerosis and acute cardiovascular diseases (Curr Med Chem. 2014;(21)35:4046-58.)

CB2 receptor stimulation attenuates the initiation and progression of atherosclerosis (Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2210-8.)

Time-Dependent Protection of CB2 Receptor Agonist in Stroke (PLoS One. 2015 Jul 17;10(7):e0132487.)

Selective Modulator of CB2 Reduces Memory Impairment and Infarct Size During Cerebral Hypoperfusion and Vascular Dementia (Curr Neurovasc Res. 2016;13(4):289-302.)

The Endocannabinoid System and Heart Disease: The Role of CB2 (Cardiovasc Hematol Disord Drug Targets. 2018;18(1):34-51.)

Selective CB2 Receptor Stimulation Reduces Tubular Epithelial Cell Damage after Renal Ischemia-Reperfusion Injury (J Pharmacol Exp Ther. 2018 Feb;364(2):287-299.)

CB2 receptor agonist decreases blood pressure of spontaneously hypertensive rats through relieving
inflammation in the rostral ventrolateral medulla of the brain (J Hypertens. 2020
May;38(5):886-895.)

β-Caryophyllene, a natural bicyclic sesquiterpene attenuates doxorubicin-induced chronic cardiotoxicity via activation of myocardial CB2 receptors in rats (Chem Biol Interact. 2019 May 1:304:158-167. )

Pharmacological characterization of the CB2 agonist, β-caryophyllene on seizure models in mice (Seizure . 2018 Apr;57:22-26.)

Targeting cannabinoid CB2 receptors in the central nervous system. Medicinal chemistry approaches with focus on neurodegenerative disorders (Front Neurosci. 2016; 10: 406.)

Central CB2 receptors in inflammation-driven neurodegeneration: dysregulation and therapeutic potential (Neural Regen Res. 2016 Sep; 11(9): 1409–1410.)

CB2 receptor: Potential role in immunomodulation and neuroinflammation (J Neuroimmune Pharmacol. 2013 Jun; 8(3): 608-620.)

Cannabinoid CB2 receptors in human brain inflammation (Br J Pharmacol. 2008 Jan; 153(2): 277–285.)

The Cannabinoid CB2 Receptor as a Target for Inflammation-Dependent Neurodegeneration (Curr Neuropharmacol. 2007 Jun; 5(2): 73–80.)

Regulatory role of the cannabinoid CB2 receptor in stress-induced neuroinflammation in mice (Br J Pharmacol. 2014 Jun;171(11):2814-26.)

CB2 receptors promote neural progenitor cell proliferation via mTORC1 signaling (J Biol Chem. 2012 Jan 6;287(2):1198-209. )

β-Caryophyllene, a CB2-Receptor-Selective Phytocannabinoid, Suppresses Mechanical Allodynia in a Mouse Model of Antiretroviral-Induced Neuropathic Pain (Molecules. 2019 Dec 27;25(1):106. )

The CB2 agonist, β-caryophyllene, improves working memory and reduces circulating levels of specific proinflammatory cytokines in aged male mice (Behav Brain Res. 2019 Oct 17;372:112012.

Pharmacological characterization of the CB2 agonist, β-caryophyllene on seizure models in mice (Seizure . 2018 Apr;57:22-26.)

Activation of CB2 receptor system restores cognitive capacity and hippocampal Sox2 expression in a transgenic mouse model of Alzheimer's disease (Eur J Pharmacol. 2017 Sep 15;811:12-20.)

CB2 cannabinoid receptor as potential target against Alzheimer’s Disease (Front Neurosci. 2016; 10: 243.)

Stimulation of brain glucose uptake by CB2 receptors and its therapeutic potential in Alzheimer's disease (Neuropharmacology. 2016 Nov;110(Pt A):519-529.)

Activation of CB2 receptors stimulates beta-amyloid removal by human macrophages (Brain Res. 2009 Aug 4;1283:148-54.)

Cannabinoid type 2 (CB2) receptors activation protects against oxidative stress and neuroinflammation associated dopaminergic neurodegeneration in rotenone model of Parkinson’s Disease (Front Neurosci. 2016; 10: 321.)

CB2 receptor activation prevents glial-derived neurotoxic mediator production, BBB leakage and peripheral immune cell infiltration and rescues dopamine neurons in the MPTP model of Parkinson’s disease (Exp Mol Med. 2016 Jan; 48(1): e205.)

CB2 receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies (Br J Pharmacol. 2008 Jan; 153(2): 216–225.)

Potent immunomodulatory activity of a highly selective cannabinoid CB2 agonist on immune cells from healthy subjects and patients with multiple sclerosis. (J Neuroimmunol. 2017 Feb 15;303:66-74.)

Regulatory role of the cannabinoid CB2 receptor in stress-induced neuroinflammation in mice (Br J Pharmacol. 2014 Jun;171(11):2814-26.)

(-)-β-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor Paralysis and Neuroinflammation in a Murine Model of Multiple Sclerosis (Int J Mol Sci. 2017 Apr 1;18(4):691.)

CB2 as a potential therapeutic target in rheumatoid arthritis (Musculoskeletal Disorders. 2014; 15: 275.)

Expression of CB2 and its inhibitory effects on synovial fibroblasts in rheumatoid arthritis (Rheumatology. 2014; 53(5): 802-809.)

Role of CB2 in mediating inflammation in rheumatoid arthritis synovial fibroblasts (Clin Exp Rheumatol. 2019 Nov-Dec;37(6):1026-1035.)

Cannabinoid CB2 receptors regulate central sensitization and pain responses associated with osteoarthritis of the knee joint (PLoS One. 2013; 8(11): e80440.)

Expression of cannabinoid receptors in human osteoarthritic cartilage: Implications for future therapies (Cannabis Cannabinoid Res. 2016 Jan 1;1(1):3-15)

A CB2 receptor agonist attenuates bone cancer-induced pain and bone loss (Life Sci. 2010 Apr 24; 86(17-18): 646–653.)

Disease Modification of Breast Cancer–Induced Bone Remodeling by CB2 Receptor Agonists (J Bone Miner Res. 2013 Jan; 28(1): 92–107.)

Cannabinoid CB2 receptor stimulation delays rubrospinal mitochondrial-dependent degeneration and improves functional recovery after spinal cord injury (Cell Death Dis. 2014 Sep 4;5(9):e1404.)

Delayed Systemic Treatment with CB2 Agonist Mitigates Spinal Cord Injury-Induced Osteoporosis More Than Acute Treatment Directly after Injury (2021 Jun 22;2(1):270-284.) 

Peripheral cannabinoid receptor, CB2, regulates bone mass (Proc Natl Acad Sci USA. 2006 Jan 17; 103(3): 696–701.)

The Role of CB2 in the Bone Loss Associated With Pediatric Celiac Disease (J Pediatr Gastroenterol Nutr. 2020 Nov;71(5):633-640.)

CB2 and TRPV1 receptors oppositely modulate in vitro human osteoblast activity (Pharmacol Res. 2015 Sep;99:194-201.)

CB2 cannabinoid receptor targets mitogenic Gi protein-cyclin D1 axis in osteoblasts (J Bone Miner Res. 2011;26(2):308-316.) 

CB2: Potential role in immunomodulation and neuroinflammation (J Neuroimmune Pharmacol2013 Jun; 8(3): 608-620.)

Emerging role of the CB2 cannabinoid receptor in immune regulation and therapeutic prospects (Expert Rev Mol Med. 2009 Jan 20; 11: e3.)

CB2: a good friend in the gut (Neurogastroenterol. Motil. 2007 Sept;19(9):704-8.)

CB2 receptor-induced relief of hypermotility in a rat model of the irritable bowel syndrome (Neurogastroenterol Motil. 2019 Jun;31(6):e13613.)

Cannabinoids and intestinal motility: welcome to CB2 receptors (Br J Pharmacol. 2004 Aug;142(8):1201-2.)

CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation (Br J Pharmacol. 2008 Jan;153(2):263-70.)

Activation of CB2 receptor relieves colonic hypermotility in a rat model of irritable bowel syndrome (Neurogastroenterol. Motil. 2019 Jun;31(6):e13555.)

CB2 agonist relieves colitis in mice by attenuating the activation of T cells and promoting their apoptosis (Toxicol Appl Pharmacol. 2012 Jan 15;258(2):256-67. )

Activation of CB2 receptors as a potential therapeutic target for migraine: evaluation in an animal model (J Headache Pain. 2014; 15(1): 14.)

Inflammation and CB2 signaling drive novel changes in the ocular lipidome and regulate immune cell activity in the eye (Prostaglandins Other Lipid Mediat. 2018 Nov;139:54-62.)

CB2 receptors are upregulated with corneal injury and regulate the course of corneal wound healing (Exp Eye Res. 2019 May;182:74-84.)

Activation of CB2 by selective agonists regulates the deposition and remodelling of the extracellular matrix (Biomed Pharmacother. 2017 Nov;95:1704-1709.)

CB2 receptor is a novel anti-inflammatory target in experimental proliferative vitreoretinopathy (Neuropharmacology. 2017 Feb;113(Pt B):627-638.)

CB2 receptor activation reduces leukocyte adhesion and improves capillary perfusion in the iridial microvasculature during systemic inflammation (Clin Hemorheol Microcirc. 2015;61(2):237-49.)

CB2 exerts antifibrotic effects in experimental dermal fibrosis (Arthritis Rheum. 2009 Apr;60(4):1129-36.)

Antifibrogenic role of the cannabinoid receptor CB2 in the liver (Gastroenterology. 2005 Mar;128(3):742-55.)

CB2 Receptor Agonist Attenuates Inflammation, Apoptosis and Stimulate Progenitor Cells in Bile Duct Ligated Rat (Open Access Maced J Med Sci. 2019 Mar 29;7(6):925-936.)

A new CB2 agonist attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury (Br J Pharmacol. 2012 Apr;165(8):2462-78.

Selective CB2 Receptor Stimulation Reduces Tubular Epithelial Cell Damage after Renal Ischemia-Reperfusion Injury (J Pharmacol Exp Ther. 2018 Feb;364(2):287-299.)

Activation of CB2 inhibits experimental cystitis (Am J Physiol Regul Integr Comp Physiol. 2013 May 15;304(10):R846-53.)

Activation of CB2 reduces inflammation in acute experimental pancreatitis (AM J Physiol Gastrointest Liver Physiol. 2013 Jan 15;304(2):G181-92.)

The role of CB2 receptors in acute pancreatitis (Pancreas. 2008 Nov;37(4):493-494.

CB2 receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell (Cell Calcium. 2006 Feb;39(2):155-62.)

Therapeutic potential of CB2 in the treatment of diabetes mellitus and its complications (Eur J Pharmacol. 2019 Nov 5;862:172628.)

CB2 agonist attenuates pain related behavior in rats with chronic alcohol/high fat diet induced pancreatitis (Mol Pain. 2014 Nov 17;10:66.)

CB2 agonist prevents nicotine induced lung fibrosis (Exp Lung Res. 2018 Sep;44(7):344-351.)

CB2 receptors regulate natural killer cells that limit allergic airway inflammation in a murine model of asthma (Allergy. 2017 Jun;72(6):937-947.)

CB2 receptor involvement in the treatment of substance use disorders (Biomolecules. 2021 Nov; 11(11): 1556.)

Role of cannabinoid CB2 receptor in the reinforcing actions of ethanol (Addict Biol. 2015 Jan;20(1):43-55.)

CB2 agonist, β-caryophyllene, reduced voluntary alcohol intake and attenuated ethanol-induced place preference and sensitivity in mice (Pharmacol Biochem Behav . 2014 Sep;124:260-8.)

CB2 agonist prevents nicotine induced lung fibrosis (Exp Lung Res. 2018 Sep;44(7):344-351.)

Cannabinoid CB2 Receptor Activation Attenuates Fentanyl-Induced Respiratory Depression. (Cannabis Cannabinoid Res. 2020 Oct 21.)