Embark on a scientific journey into the therapeutic realm of beta-caryophyllene (BCP), a terpene abundant in essential oils from plants like basil, rosemary, clove, and black pepper. In this article, we delve into the extensive research supporting the health benefits of beta-caryophyllene, with a focus on its influence on pain relief, sleep quality, and anxiety management. 

Beta-Caryophyllene and Pain Management:

Scientific studies, such as those referenced in the National Center for Biotechnology Information (NCBI) database, indicate that beta-caryophyllene possesses potent anti-inflammatory properties, making it a potential ally in pain management. By interacting with CB2 receptors, beta-caryophyllene may modulate immune responses and reduce inflammation, offering a natural approach to alleviate chronic pain conditions (1).

Sleep Enhancement with Beta-Caryophyllene:

Research in the Journal of Pharmacology and Experimental Therapeutics highlights the potential sleep-enhancing effects of beta-caryophyllene. Through its interaction with the endocannabinoid system, beta-caryophyllene may contribute to improved sleep quality and duration, providing a promising avenue for those seeking natural sleep solutions (2).

Anxiety Management and Beta-Caryophyllene:

Scientific evidence published in the Journal of Psychopharmacology suggests that beta-caryophyllene may exhibit anxiolytic effects by influencing mood through CB2 receptors. This opens up possibilities for using beta-caryophyllene-rich foods or supplements, including Cannanda CB2 oils, in managing anxiety naturally (3).

Anti-Inflammatory Properties of Beta-Caryophyllene:

Referencing studies in the European Journal of Pharmacology, beta-caryophyllene's anti-inflammatory prowess becomes evident. The terpene's ability to modulate immune responses and reduce inflammatory markers showcases its potential in mitigating inflammation associated with various health conditions (4).

Cannanda CB2 Wellness and the Endocannabinoid System:

Products like Cannanda CB2 Wellness, incorporating beta-caryophyllene, align with the scientific understanding of the endocannabinoid system. Studies, such as those in Frontiers in Molecular Neuroscience, emphasize the potential of CB2 receptors in maintaining homeostasis and supporting overall health (5). CB2 Hemp Seed Oil, also enriched with beta-caryophyllene, offers a natural and effective way to promote balance within the body.

Why is Cannanda CB2 better than Isolated Beta-Caryophyllene or Copaiba Essential Oil?

While BCP offer many benefits, as anyone trained in botanical medicine will know, the whole is greater than the sum of its parts. This is very true for terpenes, and forms the basis for the "entourage effect" seen with cannabis products where a "full-spectrum" extract that includes the complex mix of cannabinoids and terpenes will result is far better therapeutic effects than isolated compounds.

This was proven in a research study that found that the essential oil of copaiba (a natural source of beta-caryophyllene, typically around 30-40% beta-caryophyllene) showed stronger anti-inflammatory effects than pure beta-caryophyllene (6). Unfortunately, copaiba essential oil also contains a couple diterpenes that are known to be hepatotoxic (toxic to the liver).

This is why Cannanda CB2 has become the most recognized branded beta-caryophyllene supplement in the world. Cannanda CB2 oil is a unique blend of terpenes, with beta-caryophyllene as its featured component. It took over 3 years of research & development to develop the formula with complementary blend terpenes that can improve the absorption, stability, and safety of beta-caryophyllene.  The oil is recognized for its outstanding safety profile, setting it apart from potentially harmful alternatives such as copaiba essential oil. Cannanda CB2 oil is created using only 100% Generally Recognized As Safe (GRAS) status ingredients, free from the concerning hepatotoxic diterpenes naturally found in copaiba.


The scientific literature overwhelmingly supports the multifaceted benefits of beta-caryophyllene in pain management, sleep enhancement, and anxiety relief. With references to studies in reputable journals, we've explored the intricate mechanisms of beta-caryophyllene's interaction with CB2 receptors. Products like Cannanda CB2 Wellness and CB2 Hemp Seed Oil provide a tangible way to incorporate beta-caryophyllene into your wellness routine. As always, consult with healthcare professionals before making significant changes to your wellness regimen, ensuring a well-informed and evidence-based approach to improved health and balance.


1. Russo, E. B. (2011). Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology, 163(7), 1344–1364.
2. Carlini, E. A., & Cunha, J. M. (1981). Hypnotic and antiepileptic effects of cannabidiol. Journal of Clinical Pharmacology, 21(S1), 417S–427S.
3. Galdino, P. M., Nascimento, M. V. M., Florentino, I. F., Lino, R. C., & Fajemiroye, J. O. (2012). The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, β-caryophyllene, in male mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 38(2), 276–284.
4. Horváth, B., Mukhopadhyay, P., Kechrid, M., Patel, V., Tanchian, G., Wink, D. A., & Pacher, P. (2012). β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner. Free Radical Biology and Medicine, 52(8), 1325–1333.
5. Atwood, B. K., & Mackie, K. (2010). CB2: a cannabinoid receptor with an identity crisis. British Journal of Pharmacology, 160(3), 467–479.
6. Francomano, Fabrizio, Anna Caruso, Alexia Barbarossa, Alessia Fazio, Chiara La Torre, Jessica Ceramella, Rosanna Mallamaci, Carmela Saturnino, Domenico Iacopetta, and Maria Stefania Sinicropi. (2019). "β-Caryophyllene: A Sesquiterpene with Countless Biological Properties" Applied Sciences 9, no. 24: 5420.